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Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years.

Identifieur interne : 000801 ( France/Analysis ); précédent : 000800; suivant : 000802

Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years.

Auteurs : Emanuelle Taioli [Italie] ; Laura Gaspari [Italie] ; Simone Benhamou [France] ; Paolo Boffetta [France] ; Jürgen Brockmoller [Allemagne] ; Dorota Butkiewicz [Pologne] ; Ingolf Cascorbi [Allemagne] ; Margie Clapper [États-Unis] ; Vita Dolzan [Slovénie] ; Aage Haugen [Norvège] ; Ari Hirvonen [Finlande] ; Kirsti Husgafvel-Pursiainen [Finlande] ; Ivan Kalina [Slovaquie] ; Pierre Kremers [Belgique] ; Loïc Le Marchand [États-Unis] ; Stephanie London [États-Unis] ; Agneta Rannug [Suède] ; Marjorie Romkes [États-Unis] ; Bernadette Schoket [Hongrie] ; Janeric Seidegard [Suède] ; Richard Strange [Royaume-Uni] ; Isabelle Stücker [France] ; Jordi To-Figueras [Espagne] ; Seymour Garte [États-Unis]

Source :

RBID : Hal:inserm-00266872

Abstract

BACKGROUND: A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. METHODS: The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and

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Hal:inserm-00266872

Le document en format XML

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<orgName>Recherches épidémiologiques et statistiques sur l'environnement et la santé.</orgName>
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<addrLine>Hôpital Paul Brousse 16 av Paul Vaillant Couturier 94807 VILLEJUIF CEDEX</addrLine>
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<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
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<addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
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<country>France</country>
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<country>Espagne</country>
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<orgName>Environmental and Occupational Health Sciences Institute</orgName>
<orgName type="acronym">EOHSI</orgName>
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<address>
<addrLine>Picataway, NJ</addrLine>
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<country>États-Unis</country>
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<series>
<title level="j">International Journal of Epidemiology</title>
<idno type="ISSN">0300-5771</idno>
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<date type="datePub">2003-02</date>
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<div type="abstract" xml:lang="en">BACKGROUND: A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. METHODS: The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and</div>
</front>
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<li>Allemagne</li>
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<li>Pennsylvanie</li>
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